Table 4.

Combined VBM Results Showing Posterior Cortical Atrophy and Alzheimer Disease Shared Brain Regions in Which GM Volume Reductions Were Associated With Lower Visuoperceptual, Visuospatial and Cognitive Factor Scores

	k	p FWE	T	x	y	z	Brain region
Visuoperceptual-early	2,038	0.0003	6.66	8	−75	−2	Right lingual gyrus
		0.0003	6.64	10	−74	20	Right intracalcarine cortex
		0.0003	6.48	11	−69	−4	Right occipital fusiform gyrus
	27	0.0014	5.99	42	−93	20	Right occipital pole
	26	0.0050	5.64	51	−80	8	Right lateral occipital cortex
	58	0.0169	5.26	36	−46	6	Right medial temporal gyrus
Visuospatial-early	120	0.0035	5.78	40	−36	34	Right supramarginal gyrus
	44	0.0020	6.02	50	−62	24	Right lateral occipital cortex
	28	0.0140	5.28	30	−54	44	Right superior parietal lobule
	21	0.0186	5.18	46	−28	30	Right parietal operculum
	17	0.0139	5.28	6	−46	50	Right precuneus
Cognitive	69	0.0051	5.56	−46	−42	33	Left supramarginal gyrus
	60	0.0067	5.46	−42	−48	38	Left angular gyrus
	60	0.0107	5.30	−56	−57	−2	Left medial temporal gyrus
	55	0.0411	4.85	−45	−46	18	Left inferior temporal gyrus
	24	0.0143	5.20	−39	−70	−28	Left lateral occipital cortex

Abbreviations: GM = grey matter; k = cluster size; PFWE = family-wise error corrected p value (p < 0.05); VBM = voxel-based morphometry; x, y, z = peak-voxel Montreal Neurological Institute coordinates.