Table 2.
Overview of observational and clinical trials that are included in the UNITY network.
| Study Location | Cohort Name | Study Type | Cohort Age Range | Cohort Type | Cohort Size | Imaging Timepoints |
|---|---|---|---|---|---|---|
| CEL, Lucknow, India | India Longitudinal Cohort | Longitudinal Observation Study | 3 Months - 5 Years | Healthy Community Sample | 180 | 3, 9, 15, 21, 30, 60 Months |
| Makerere University & Kawempe Referral Hospital, Uganda | PRIMES | Longitudinal Study following Nutritional Supplementation | 3–12 Months | RCT of low-birth infants with and without early nutritional supplementation for 30 days at 1 Month | 80 | 3, 6, 12 Months |
| Makerere University & Kawempe Referral Hospital, Uganda | Uganda Longitudinal Cohort | Longitudinal Observation Study | Birth - 5 Years | Healthy Community Sample | 180 | 3, 6, 12, 18, 24, 30, 36, 42, 48, 54, and 60 Months |
| University of Cape Town, South Africa | DoLPHIN 2 Plus+ | Randomized Clinical Drug Trial | 2–4 Years of Age | Observational follow up of HIV-exposed uninfected children nested within the drug trial and HIV-unexposed uninfected children from the same high-risk community. | 120 | 24–60 Months |
| University of Cape Town, South Africa | Khula | Longitudinal Observation Study | Birth - 2 Years | Healthy Community Sample | 300 | 3, 6, 12, 18, 24 Months |
| Kalafong Hospital (Pretoria) and Chris Hani Baragwanath Academic Hospital (Johannesburg), South Africa | NESHIE | Longitudinal Observation Study | 0–6 Months | Patients with moderate-severe NESHIE | 200 | 0–6 H of life*, 3–6 Days OR 7–14 Days, and 3–6 Months |
| Blantyre, Malawi | Khula | Longitudinal Observation Study | Birth - 2 Years | Healthy Community Sample | 300 | 3, 6, 12, 18, 24 Months |
| Stellenbosch University, Cape Town South Africa | BONO | Longitudinal Observation Study | Birth - 7 Years | Community Sample | 2000 | 1, 2, 3, 4, 5, 6, 7 Years |
| Korle-Bu Teaching Hospital, Ghana | Accra Neuroimaging Study | Longitudinal Observation Study | 0–12 Months | Community Sample | 120 | 3, 6, 12 Months |
| CMC Vellore, India | PRiSMA | Longitudinal Observation Study | 0–12 Months | Drawn from larger study of mothers with and without antenatal anemia | 300 | 3, 6, 12 Months |
| Kintampo Health Research Center, Ghana | PRiSMA | Longitudinal Observation Study | 0–12 Months | Drawn from larger study of mothers with and without antenatal anemia | 300 | 3, 6, 12 Months |
| Kisumu, Kenya | PRiSMA | Longitudinal Observation Study | 0–12 Months | Drawn from larger study of mothers with and without antenatal anemia | 300 | 3, 6, 12 Months |
| Lusaka, Zambia | PRiSMA / ZAPPS | Longitudinal Observation Study | 0–12 Months | Drawn from larger study of mothers with and without antenatal anemia | 300 | 3, 6, 12 Months |
| AKU Hospital, Pakistan | PRiSMA | Longitudinal Observation Study | 0–12 Months | Drawn from larger study of mothers with and without antenatal anemia | 300 | 3, 6, 12 Months |
| AKU Hospital, Pakistan | MINE | Longitudinal Observation Study | 1–36 Months | General hospital & community sample | 250 | 12, 24, 36 Months |
| Iccdr,b Bangladesh | BEAN | Cross-Sectional Observation Study | Birth - 12 Years | A community cohort longitudinal EEG, NIRS, and MRI study of neurodevelopment | 210 | 3, 12, 24, 48 and 96 Months |
| Zomba Central Hospital, Zomba | Birth Cohort | Mixed Cross-Sectional and Longitudinal Cohort | Birth - 5 Years | Community sample. | 5000 | 3, 12, 24, 36, 48, 60 Months |
| Zomba Central Hospital, Zomba | REVAMP | Longitudinal RCT | Birth - 2 Years | RCT of maternal IV-Iron infusion for the treatment of antenatal anemia | 200 | 6, 12, 24 Months |
| Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar, Ethiopia; Addis Continental Institute of Public Health | BCD (Bahirdar Child Development) | Prospective accelerated longitudinal cohort | 6 Months-5 Years | Healthy community sample | 210 | 6, 12, 18, 24, 30, 36, 42, 48, 60 Months |
| Felege Hiwot Comprehensive Specialized Hospital, Bahir Dar, Ethiopia; Addis Continental Institute of Public Health | ENAT Infant Follow up | Longitudinal Infant follow up of Offspring of ENAT study | 12–24 Months | Randomized pragmatic effectiveness study of maternal nutrition interventions (Balanced Energy protein supplement, iodized salt, IFA) and enhanced infection management (genitourinary tract infection treatment and deworming) | 60 | 12, 24 Months |