TTD in PROs with (A) STRIDE versus sorafenib and (B) durvalumab versus sorafenib. EORTC, European Organization for Research and Treatment of Cancer; GHS, global health status; HCC, hepatocellular carcinoma; HR, hazard ratio; NR, not reached; PRO, patient-reported outcome; QLQ-C30, 30-item Quality of Life Questionnaire; QLQ-HCC18, 18-item HCC Health-Related Quality of Life Questionnaire; QoL, quality of life; STRIDE, Single Tremelimumab Regular Interval Durvalumab; TTD, time to deterioration.