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. Author manuscript; available in PMC: 2024 Aug 9.
Published in final edited form as: Cell Rep. 2024 Jun 2;43(6):114289. doi: 10.1016/j.celrep.2024.114289

Figure 3. Enhanced effector T cell response in Irf1−/− tumors.

Figure 3.

(A) UMAP showing 12 distinct cell populations in WT and Irf1−/− tumors.

(B) Percentage of indicated cell populations in WT and Irf1−/− tumors.

(C) Dot plot showing expression of select cell-type-specific and immune activation genes in cells from WT and Irf1−/− tumors.

(D) Differential expression (DE) of genes enriched in the CD8-NKT cell cluster.

(E) Gene Ontology analysis of cells in the CD8-NKT cluster from Irf1−/− tumors.

(F) Projection of T cells (black profile) from WT and Irf1−/− tumor scRNA-seq onto reference T cell atlas (colored distinct T cell states) from ProjectTILs.

(G) Proportion of various T cell states in WT and Irf1−/− tumors as defined by the reference T cell atlas. All data were generated by comparison of scRNA-seq data pooled from 4 WT and 6 Irf1−/− mouse tumors.