TABLE I.
Physicochemical characteristics, including particle size, zeta potential, polydispersity index, entrapment efficiency (EE), and loading capacity (LC), of pDNA-CaP NPs determined using DLS and NanoDrop.
| Sample | z-average diametera (nm) | PDIb | Zeta potential (mV) | EE (%) | LC (%) |
|---|---|---|---|---|---|
| CaP NPs | 3082.3 ± 419.1 | 0.34 ± 0.09 | −2.75 | ⋯ | ⋯ |
| pDNA-CaP NPs | 393.9 ± 2.9 | 0.27 ± 0.01 | −10.8 | 62.0 ± 13.4 | 15.9 ± 3.3 |
a
z-average diameter is the average diameter calculated based on the intensity of scattered light.
b
PDI = polydispersity index, a measure of the ratio between the weight-average particle diameter and the number-average particle diameter.