Table 2.
Odds ratio for VTE (venous thromboembolism) for disease clusters F1-F9 according to multimorbidity score (0 to ≥ 5). Odds Ratios (ORs) with 95% confidence interval (CI). Reference with no diseases (score = 0)
| All (n = 2,694,442) | OR (95% CI) | OR (95% CI) | ||
|---|---|---|---|---|
| Score (0 to ≥ 5) | No VTE | VTE | Model 1 | Model 2 |
| F1 = hypertension, heart failure, coronary heart disease, diabetes, obesity, atrial fibrillation, gout, atherosclerosis, and renal disease (9 diseases) | ||||
| F1 Score 0 | 2,480,568 | 11,902 | 1[Reference] | 1[Reference] |
| F1 Score 1 | 163,960 | 2885 | 3.67 (3.52–3.82) | 2.92 (2.80–3.04) |
| F1 Score 2 | 24,713 | 842 | 7.10 (6.61–7.62) | 3.80 (3.53–4.08) |
| F1 Score 3 | 6729 | 278 | 8.61 (7.63–9.72) | 3.93 (3.48–4.45) |
| F1 Score 4 | 1716 | 126 | 15.30 (12.76–18.35) | 6.39 (5.32–7.68) |
| F1 Score ≥ 5 | 657 | 66 | 20.94 (16.25–26.98) | 8.17 (6.32–10.55) |
| F2 = affective disorders, anxiety, psychoactive substance misuse, alcohol misuse disorders, anorexia or bulimia, and schizophrenia disorders (6 diseases) | ||||
| F2 Score 0 | 2,348,952 | 12,307 | 1[Reference] | 1[Reference] |
| F2 Score 1 | 203,723 | 1990 | 1.86 (1.78–1.96) | 1.73 (1.65–1.82) |
| F2 Score 2 | 89,520 | 1086 | 2.32 (2.18–2.47) | 2.05 (1.93–2.19) |
| F2 Score 3 | 27,098 | 458 | 3.23 (2.94–3.54) | 2.85 (2.59–3.13) |
| F2 Score 4 | 8228 | 229 | 5.31 (4.65–6.06) | 4.43 (3.88–5.07) |
| F2 Score ≥ 5 | 822 | 29 | 6.73 (4.65–9.76) | 6.31 (4.34–9.17) |
| F3 = inflammatory bowel disease, liver disease, pancreatic disease, and ulcers (4 diseases) | ||||
| F3 Score 0 | 2,628,503 | 14,948 | 1[Reference] | 1[Reference] |
| F3 Score 1 | 46,867 | 1025 | 3.85 (3.61–4.10) | 2.69 (2.52–2.87) |
| F3 Score 2 | 2750 | 109 | 6.97 (5.75–8.45) | 4.28 (3.53–5.20) |
| F3 Score 3 | 209 | 15 | 12.66 (7.50–21.37) | 7.59 (4.46–12.91) |
| F3 Score 4 | 14 | 2 | 25.12 (5.71–110.54) | 15.5 (3.33–68.88) |
| F3 Score ≥ 5 | NA | NA | NA | NA |
| F4 = epilepsy, blindness and poor vision, cerebrovascular disease, cancer, and impaired or hearing loss (5 diseases) | ||||
| F4 Score 0 | 2,530,129 | 12,987 | 1[Reference] | 1[Reference] |
| F4 Score 1 | 138,540 | 2630 | 3.70 (3.55–3.86) | 2.72 (2.60–2.84) |
| F4 Score 2 | 8686 | 415 | 9.31 (8.42–10.29) | 6.24 (5.64–6.91) |
| F4 Score 3 | 911 | 62 | 13.26 (10.25–17.16) | 9.14 (7.03–11.89) |
| F4 Score 4 | 73 | 4 | 10.68 (3.90–29.21) | 7.16 (2.57–19.98) |
| F4 Score ≥ 5 | 4 | 1 | 48.71 (5.44–435.79) | 20.74 (2.10–204.30) |
| F5 = connective tissue disease, osteoporosis, thyroid disorders, and psoriasis; (4 diseases) | ||||
| F5 Score 0 | 2,561,719 | 14,197 | 1[Reference] | 1[Reference] |
| F5 Score 1 | 110,916 | 1707 | 2.78 (2.64–2.92) | 1.98 (1.89–2.09) |
| F5 Score 2 | 5463 | 184 | 6.08 (5.24–7.05) | 3.57 (3.07–4.14) |
| F5 Score 3 | 243 | 11 | 8.17 (4.47–14.96) | 3.85 (2.09–7.09) |
| F5 Score 4 | 2 | 0 | NA | NA |
| F5 Score ≥ 5 | NA | NA | NA | NA |
| F6 = prostate disease, arthrosis, painful back condition, diverticular disease of intestine, and chronic sinusitis (5 diseases) | ||||
| F6 Score 0 | 2,460,459 | 12,471 | 1[Reference] | 1[Reference] |
| F6 Score 1 | 202,887 | 3122 | 3.04 (2.92–3.16) | 1.90 (1.82–1.97) |
| F6 Score 2 | 14,277 | 459 | 6.34 (5.77–6.97) | 2.82 (2.56–3.10) |
| F6 Score 3 | 688 | 45 | 12.90 (9.54–17.46) | 4.90 (3.61–6.64) |
| F6 Score 4 | 31 | 2 | 12.73 (3.05–53.19) | 4.93 (1.17–20.72 |
| F6 Score ≥ 5 | 1 | 0 | NA | NA |
| F7 = bronchiectasis, Parkinson’s disease, glaucoma, learning disability, and irritable bowel syndrome (5 diseases) | ||||
| F7 Score 0 | 2,634,690 | 15,572 | 1[Reference] | 1[Reference] |
| F7 Score 1 | 43,403 | 525 | 2.05 (1.88–2.23) | 1.73 (1.58–1.89) |
| F7 Score 2 | 249 | 2 | 1.36 (0.34–5.46) | 0.92 (0.28–3.71) |
| F7 Score 3 | NA | NA | NA | NA |
| F7 Score 4 | NA | NA | NA | NA |
| F7 Score ≥ 5 | NA | NA | NA | NA |
| F8 = asthma, dermatitis and eczema, constipation, chronic obstructive pulmonary disease, and migraine (5 diseases) | ||||
| F8 Score 0 | 2,277,416 | 12,571 | 1[Reference] | 1[Reference] |
| F8 Score 1 | 343,860 | 2856 | 1.50 (1.44–1.57) | 1.80 (1.73–1.88) |
| F8 Score 2 | 51,902 | 570 | 1.99 (1.83–2.16) | 3.15 (2.89–3.43) |
| F8 Score 3 | 4902 | 97 | 3.58 (2.93–4.39) | 6.19 (5.03–7.60) |
| F8 Score 4 | 259 | 5 | 3.50 (1.44–8.48) | 4.51 (1.83–11.10) |
| F8 Score ≥ 5 | 4 | 0 | NA | NA |
| F9 = multiple sclerosis and dementia (2 diseases) | ||||
| F9 Score 0 | 2,672,359 | 15,988 | 1[Reference] | 1[Reference] |
| F9 Score 1 | 5978 | 111 | 3.10 (2.57–3.75) | 1.86 (1.54–2.24) |
| F9 Score 2 | 6 | 0 | NA | NA |
| F9 Score 3 | NA | NA | NA | NA |
| F9 Score 4 | NA | NA | NA | NA |
| F9 Scpre ≥ 5 | NA | NA | NA | NA |
OR = odds ratio; NA = not applicable due to few cases. Model 1 is a crude model. Model 2 is adjusted for sex, year of birth, region at birth, and educational attainment