Table 2.
MR analysis results, heterogeneity test, and pleiotropy test results of the common malignant tumors in the female reproductive system with SLE
| Outcome | MR method | SNPs | OR | 95%CI | P | Heterogeneity P-value Pheterogeneity |
Global test P-value Ppleiotropy |
|---|---|---|---|---|---|---|---|
| cervical cancer | MR Egger | 20 | 0.9999674 | 0.9994036–1.000532 | 0.9111910 | 0.8708548 | 0.9797716 |
| Weighted median | 20 | 0.9999489 | 0.9996401–1.000258 | 0.7396628 | |||
| IVW | 20 | 0.9999742 | 0.9997520–1.000197 | 0.8203584 | 0.9049602 | ||
| Simple mode | 20 | 0.9999755 | 0.9994363–1.000515 | 0.9227421 | |||
| Weighted mode | 20 | 0.9999569 | 0.9996159–1.000298 | 0.8112230 | |||
| endometrial cancer | MR Egger | 42 | 0.9858688 | 0.9272318–1.048214 | 0.6516376 | 0.5363098 | 0.7257479 |
| Weighted median | 42 | 0.9645530 | 0.9230065–1.007970 | 0.0888895 | |||
| IVW | 42 | 0.9763169 | 0.9483927–1.005063 | 0.1054741 | 0.5751958 | ||
| Simple mode | 42 | 0.9692011 | 0.8924385–1.052566 | 0.3968641 | |||
| Weighted mode | 42 | 0.9692011 | 0.9178899–1.023381 | 0.2707590 | |||
| ovarian cancer | MR Egger | 31 | 1.0270407 | 0.9671607–1.090628 | 0.3911492 | 0.4025248 | 0.6346761 |
| Weighted median | 31 | 0.9905470 | 0.9645862–1.027502 | 0.4925948 | |||
| IVW | 31 | 0.9878039 | 0.9666491–1.009608 | 0.2722005 | 0.4372107 | ||
| Simple mode | 31 | 1.0084270 | 0.9593472–1.060018 | 0.7439524 | |||
| Weighted mode | 31 | 0.9939198 | 0.9531501–1.036433 | 0.6154643 |