Skip to main content
. 2024 Jul 5;24(2):263–274. doi: 10.1007/s40268-024-00468-4

Table 2.

Rank-order of potency for three BTK inhibitors

graphic file with name 40268_2024_468_Tab2_HTML.jpg

Classical kinase screening assays measuring phosphokinase activity were conducted using recombinant BTK protein and a fluorescent peptide pseudosubstrate in the presence of 16 µM ATP and defined concentrations of inhibitor. The concentration response curve (right panel) was fit to a normal hyperbola adjusted using a logit calculation to estimate the IC50 and Hill slope for each test article. Results represent the average of two independent determinations