Table 3.
Integrated PK–PD–efficacy model parameter estimate for xenografts (786-O)
| Parameter | Unit | Estimate | RSE% | Variability% | Shrinkage% |
|---|---|---|---|---|---|
| Kg | 1/h | 0.0057 | 3.9 | – | – |
| Kmax | 1/h | 0.0194 | 43.2 | – | – |
| KI50 | %pAKT inhibition | 67.2 | 12.6 | – | – |
| γ2 | – | 9.4 | 208.5 | – | – |
| Proportional error | – | 0.248 | 5.1 | – | – |
| IIV Kg | Variance | 0.0276 | 29.6 | 16.6 | 22.6 |
| IIV Kmax | Variance | 0.0529 | 54.6 | 23.0 | 45.8 |
IIV, interindividual variability; Kg, net tumor growth rate constant; Kmax, maximum value of Ks; KI50, I where Ks is 50% of Kmax; RSE, relative standard error; γ2, sigmoidicity factor of the sigmoid Kmax equation