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. 2024 Aug 9;15(8):583. doi: 10.1038/s41419-024-06977-z

Fig. 8. Elevated expression of Wnt/β-catenin signaling, non-canonical NF-κB, and NRF2 pathways/genes.

Fig. 8

A Analyses of transcriptomic data from STAM vs. Chow described in [28, 29]. Plots showing the expression (TPM) of genes associated with activation of Wnt/β-catenin signaling, non-canonical NF-κB, and NRF2 in livers of STAM vs. Chow-fed mice. B Analyses of transcriptomic data from human HCCs expressing MIR17HG.high, grade III (n = 68) vs. normal liver (n = 50) from TCGA.LIHC. MIR17HG.high samples are defined by stratifying TCGA.LIHC patients (tumor data only) into 4 quantiles by expression (TPM) for MIR17HG. Patients stratified into top two quantiles (n = 185) were denoted as “MIR17HG.high” group (Table S5). Plots showing the expression (TPM) of genes associated with activation of Wnt/β-catenin signaling, non-canonical NF-κB, and NRF2. Error bars indicate mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001; ****; p < 0.0001 by unpaired t-test.