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. 2024 Aug 10;7:972. doi: 10.1038/s42003-024-06655-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 6 — A Micro-CT images of calvarial bone defects after 8 weeks. B Quantitative analysis of newly formed bone parameters, bone volume/total volume (BV/TV), bone surface/total volume (BS/TV), bone mineral density (BMD), trabecular thickness (Tb.Th), trabecular number (Tb.N) and trabecular separation (Tb.Sp) (n = 8). Representative microscopic images of histological tissue sections: C HE staining and D Masson staining. Osteoblast (yellow arrows); Vessel (red arrows). Significant difference compared different groups, *P < 0.05, **P < 0.01, and ***P < 0.001; compared between DPSC and CBD+DPSC groups in blue; compared between DPSC and spheroids groups in red; compared between spheroids and CBD+spheroids groups in green; compared between CBD+DPSC and CBD+spheroids groups in purple.