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. 2024 Jun 27;25(8):3406–3431. doi: 10.1038/s44319-024-00186-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Figure EV3 — (A, B) Single marker images (VIM, αSMA, C3, MHCII, EPCAM, CD45, DAPI) and merge of all channels for the representative images of Fib^Ctrl (A) and Fib^ΔZeb1 (B) orthotopic tumors shown in Fig. 2K. (C) Normalized staining intensities of CAF markers (αSMA, C3, MHCII) in UMAP embedding of CAFs from Fib^Ctrl and Fib^ΔZeb1 tumors. (D) Quantification of the distribution of CAF subtypes based on thresholds for αSMA (myCAF-like), C3 (iCAF-like) or MHCII (apCAF) staining intensity (n = 5/6 independent mice for Fib^Ctrl/Fib^ΔZeb1, myCAF: P = 0.0469, iCAF: P = 0.0499, Student’s t test). Data information: Data are presented as mean ± SD (D). Scale bars represent 100 µm (A, B). Source data are available online for this figure.