Table 1. Generation of mosaic mice.

Targeted gene	Mating pairs	Total offspring	Double transgenics	Mosaic mice
IGF-IR	15	105	41a	23
AMPK	10	85	23	21

^aExperiments were carried out using heterozygous loxP and heterozygous EIIaCre mice, except for some homozygous IGF-IRneolox F0 females, which explains the higher frequency of double transgenics in F1 (see also Fig. 1).