Table 2:
Kidney biopsy characteristics.
| Non-ICI-AIN | ICI-AIN | |||
|---|---|---|---|---|
| N = 11 | N = 17 | P value | ||
| Infiltrate intensity | Mild | 1/11 (9.1%) | 3/17 (17.6%) | P = .63 |
| Moderate | 4/11 (36.4%) | 6/17 (35.3%) | ||
| Severe | 6/11 (54.5%) | 8/17 (47.1%) | ||
| Granulomas (% patients) | 1/11 (9.1%) | 4/17 (23.5%) | P = .62 | |
| Eosinophils (% patients) | 6/11 (54.5%) | 13/17 (76.5%) | P = .41 | |
| Plasma cells (% patients) | 5/11 (45.5%) | 5/17 (29.4%) | P = .044 | |
| ATN (% patients) | 4/11 (36.4%) | 3/17 (17.6%) | P = .38 | |
| Fibrosis (% patients) | 6/11 (54.5%) | 10/17 (58.8%) | P ≥ .99 | |
| Tubulitis (% patients) | 6/11 (54.5%) | 10/17 (58.8%) | P ≥ .99 |
ATN: Patients showing any degree of acute tubular necrosis. Non-ICI-AIN—cute interstitial nephritis not related to checkpoint inhibitor therapy.