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Mutation distribution downstream of the plasmid origin. Twenty LacI– and 24 Lipase– independent mutants isolated from GMEc6 (Pol I* MutHLS–) were sequenced. The thin line represents plasmid sequences, the bent arrow, the initiation site of DNA replication at ori and the bold lines, the reporter genes. Dots denote positions of mutations. In lacI, 14 different mutated bases were observed, one occurred seven times and another twice.
