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. Author manuscript; available in PMC: 2025 Aug 1.
Published in final edited form as: Transfusion. 2024 Jun 17;64(8):1469–1480. doi: 10.1111/trf.17922

Figure 2. Testosterone therapy (TT)-related changes in RBC membrane deformability and hydration state (viscosity).

Figure 2.

RBC indices of membrane deformability (maximal elongation index, EImax) and viscosity (elongation index at the hypertonic region, EIhyper) were collected (LORRCA Osmoscan module) from 7 individuals before and after testosterone replacement therapy (TT) initiation. TT-1, TT-2, and TT-3, 1–2 months, 5–6 months, and 10–12 months after TT initiation (Pre-TT). N=6–7. A. Longitudinal measurements of EImax. *, p<0.05 compared with Pre-TT. B. Longitudinal measurements of EIhyper. *, p=0.026 compared with Pre-TT. A and B, before-after plots. Each symbol represents a unique individual. C. Pearson correlation analyses between individuals’ plasma free testosterone and EImax. r, Pearson correlation coefficient.