FIG. 5.

Neutralizing titers induced to VSV vectors following sequential boosting with G protein exchange vectors. Groups of five to seven mice were inoculated sequentially i.n. with the G(I) vector, followed by boosting with the G(Ch) vector at 1 month and boosting with the G(NJ) vector at 2 months. Neutralizing antibody titers to all three VSV G proteins were determined in sera taken at 1, 2, and 3 months, as indicated. Bars at the baseline indicate undetectable cross-neutralization (titer of less than 1:8).