Fig. 1.

Trpc1^−/− mice are heavier. (A) In one group displaying increased calorie intake, we measured serial body weights in wild-type (n=11) and Trpc1^−/− mice (n=12) from the 4th through the 17th months of age. We observed noticeable and significant (P<0.05 to <0.001) obesity beginning at the 8th month in Trpc1^−/− mice vs Trpc1^+/+ wild type. (B) Obesity in male Trpc1^−/− mice (n=22–45) was documented from the 5–6th weeks of age through the 26th week compared to Trpc1^+/+ wild type (n=20–40) and Trpc1^+/− heterozygote littermates (n=10–63). P<0.001, Trpc1^−/− vs wild type, 4th through 30th week; P<0.03, Trpc1^−/− vs heterozygotes, 5th through 30th week; not significantly different between the wild type and the heterozygotes. (C) At 6 weeks, there was a difference in body morphology between littermate Trpc1^+/+ mice and Trpc1^−/− mice that were born to a common mother excluding maternal influence. Trpc1^−/− male mice also displayed morphological differences from age-matched Trpc1^+/+ mice purchased from Taconic lab at 14 months of age or purchased from Jackson labs at 17 months of age.