Skip to main content
. 2024 Jun 19;52(14):8271–8285. doi: 10.1093/nar/gkae519

Figure 1.

Figure 1.

DNA repair determinants of formaldehyde tolerance in C.elegans. (A) Cartoon showing the putative lesions caused on DNA by formaldehyde (FA). In blue the factors inactivated in this work. Light blue shows some factors that might participate in multiple DNA repair pathways. (B) Scheme of the protocol applied to address FA tolerance and development in the data shown in C and D (see Materials and methods for details). (C) Heatmap summarizing survival data for C. elegans mutants in DNA repair and upon downregulation of adh-5 via RNAi. (D) Heatmap summarizing animals reaching adulthood as measure of development proficiency for C. elegans mutants in DNA repair and upon silencing of ADH-5. The heatmaps contain the mean value of three independent biological replicates for each condition. The significance was determined via a two-way ANOVA and the Dunnett's multiple comparisons test, for which counts *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. The full statistical analysis for (C) and (D) is available as supplementary tables. Cartoons were created with BioRender.com.