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. 2024 Jun 19;52(14):8271–8285. doi: 10.1093/nar/gkae519

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© The Author(s) 2024. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Loss of ADH-5 does not shorten the lifespan of animals deficient for xpa-1 and csb-1, while formaldehyde-sensitivity is increased. (A) and (B) show full lifespan experiments of wildtype and adh-5 mutants, while (A) includes csb-1 and csb-1;adh-5 mutants, and (B) includes xpa-1 and xpa-1;adh-5 deficient animals. In (C) and (D), animals were exposed to 5 mM formaldehyde (FA) from the L4 stage and lifespan was determined for (C) animals deficient in csb-1 and csb-1;adh-5, and (D) mutants for xpa-1 and xpa-1;adh-5. The significance between conditions was determined via the log-rank (Mantel-Cox) test, for which is defined ****P < 0.0001.