Table 2. PDAC subjects with pathogenic germline variants (PGVs) in pancreatitis genes as compared to other germline variants.
A significant number of PDAC patients were identified with PGVs in pancreatitis genes. Demographic data, self-reported family history, and staging information was evaluated among those with pancreatitis associated PGVS (Pancreatitis), non-pancreatitis associated PGVS (Germline) and compared both groups to those without any PGVs (Neither)
| Age at testing | 0.5086 | 0.1234 | |||
| N | 66 | 186 | 950 | ||
| Mean (SD) | 67.2 (10.8) | 65.0 (10.9) | 66.3 (10.3) | ||
| Range | (40.0–83.0) | (32.0–85.0) | (19.0 – 89.0) | ||
| Sex | 0.3445 | 0.0334 | |||
| Female | 28 (42.4%) | 76 (40.0%) | 464 (48.4%) | ||
| Male | 38 (57.6%) | 114 (60.0%) | 494 (51.6%) | ||
| Clinician-reported ancestry | 0.3500 | 0.2118 | |||
| Missing | 10 | 16 | 75 | ||
| Asian | 1 (1.8%) | 3 (1.7%) | 47 (5.3%) | ||
| Black/African-American | 1 (1.8%) | 5 (2.9%) | 22 (2.5%) | ||
| Hispanic | 2 (3.6%) | 9 (5.2%) | 30 (3.4%) | ||
| Jewish | 3 (5.4%) | 10 (5.7%) | 32 (3.6%) | ||
| Other | 2 (3.6%) | 17 (9.8%) | 96 (10.9%) | ||
| White/Caucasian | 47 (83.9%) | 130 (74.7%) | 656 (74.3%) | ||
| Family History | 0.7502 | 0.9705 | |||
| Missing | 46 | 125 | 616 | ||
| no | 2 (10.0%) | 10 (15.4%) | 52 (15.2%) | ||
| yes | 18 (90.0%) | 55 (84.6%) | 290 (84.8%) | ||
| Cancer Stage | 0.7813 | 0.9503 | |||
| Missing | 50 | 130 | 640 | ||
| 0/1A/1B | 2 (12.5%) | 8 (13.3%) | 37 (11.6%) | ||
| IIA/IIB | 1 (6.3%) | 10 (16.7%) | 50 (15.7%) | ||
| III | 2 (12.5%) | 11 (18.3%) | 54 (17.0%) | ||
| IV | 11 (68.8%) | 31 (51.7%) | 177 (55.7%) |