Figure 2.

Ubiquitin Specific Peptidase 7 (USP7) regulates the stability of P53 and thereby the transcription of DNA Methyltransferase 1 (DNMT1). In the absence of cellular stress, USP7 has an interaction with Mouse Double Minute 2 Homolog 2 (MDM2), thereby stabilizing it. This leads to the degradation of P53, because this protein is ubiquitinated by MDM2. This allows Specificity Protein 1 (SP1) to bind to the DNMT1 promoter, thereby activating its transcription. If cellular stress is present, USP7 has an interaction with P53 through the interference of Guanosine Monophosphate Synthetase (GMPS). This has the result that P53 binds to SP1, preventing it from binding to the DNMT1 promoter. This inhibits the transcription of DNMT1 (Created with BioRender).