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. 2024 Aug 11;10:359. doi: 10.1038/s41420-024-02132-x

Fig. 6. Knockdown integrin β3 or blocked PI3K/Akt signaling pathway abolished the rhMFGE8 treatment effects on neurological function.

Fig. 6

A Experimental design, animal groups and time frame of the analyses in experiment 4. B Modified Garcia score and beam balance score show that rhMFGE8 treatment improves the scores, with the effect reversed by int-β3 siRNA and PI3K/Akt inhibitor. C Representative western blot bands and (D–K). Quantitative analyses of MFGE8, int β3, PI3K, p-Akt, Akt, mTOR, cyclin D1, HPCA and DCX at 24 hr after SAH. **P < 0.01 vs sham group; ##P < 0.01 vs. SAH+vehicle group; $$ P < 0.01 vs. SAH + rhMFGE8+ scr siRNA; && P < 0.01 vs. SAH+rhMFGE8 + vehicle. Data were represented as mean ± SD. One-way ANOVA, Tukey’s test, n = 6 per group.