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. 2024 Aug 12;14(34):25042–25047. doi: 10.1039/d4ra04727c

Cytotoxic activities of pregnane steroids 1–9 against breast cancer MCF-7 cell lines.

No. Compound IC50 (μM)
1 Pachylenone A (1) 768.73
2 Pachylenone B (2) >1000
3 5α-Dihydroprogesterone (3) >1000
4 GSD-8 (4) >1000
5 trans-5α-Pregn-l7(20)-en-3,16-dion (5) >1000
6 20β-Hydroxy-5αH-pregnan-3-one (6) 568.76
7 3β-Hydroxy-5α-pregnan-20-one (7) >1000
8 Aglaiasterol B (8) 228
9 2β,3β-Dihydroxypregnan-16-one (9) >1000
Positive control (Cisplatin) 43.18