Cytotoxic activities of pregnane steroids 1–9 against breast cancer MCF-7 cell lines.
No. | Compound | IC50 (μM) |
---|---|---|
1 | Pachylenone A (1) | 768.73 |
2 | Pachylenone B (2) | >1000 |
3 | 5α-Dihydroprogesterone (3) | >1000 |
4 | GSD-8 (4) | >1000 |
5 | trans-5α-Pregn-l7(20)-en-3,16-dion (5) | >1000 |
6 | 20β-Hydroxy-5αH-pregnan-3-one (6) | 568.76 |
7 | 3β-Hydroxy-5α-pregnan-20-one (7) | >1000 |
8 | Aglaiasterol B (8) | 228 |
9 | 2β,3β-Dihydroxypregnan-16-one (9) | >1000 |
Positive control | (Cisplatin) | 43.18 |