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. 2024 Apr 16;20(2):533–547. doi: 10.4103/NRR.NRR-D-23-01525

Figure 3.

Figure 3

GGT5 overexpression in cerebrovascular endothelial cells improves learning and memory in APP/PS1 mice.

(A, B) Histograms of total arm entries (A) and the percentage of correct spontaneous alternations (B) within 8 minutes in the Y-maze. (C, D) The average swimming speed (C) and escape latency (D) during the positioning navigation test for the mice in each group. (E) Representative swimming trajectories of mice from each group in the positioning navigation test on the 5th training day. (F, G) Histograms of the percentage of time spent swimming in the target quadrant (F) and the number of platform crossings (in 60 seconds) (G) in the probe trial. (H) Representative swimming trajectories of mice from each group in the probe trial. Data are expressed as mean ± SEM (n = 10 per group). *P < 0.05, **P < 0.01, ***P < 0.001, APP/PS1 + Vector group vs. WT + Vector group; #P < 0.05, ##P < 0.01, APP/PS1 + GGT5 group vs. APP/PS1 + Vector group (in D) (one-way analysis of variance followed by Tukey’s post hoc test [A, B, F and G], two-way analysis of variance with repeated measures followed by Tukey’s post hoc test [C and D]). GGT5: Gamma-glutamyltransferase 5; WT: wide type.