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. 2024 Apr 16;20(2):533–547. doi: 10.4103/NRR.NRR-D-23-01525

Figure 6.

Figure 6

GGT5 overexpression in cerebrovascular endothelial cells reduces the Aβ load in the brains of APP/PS1 mice by inhibiting BACE1.

(A–F) Representative western blots (each row is an image from a different blot) (A) and quantitative analysis of flAPP (B), CTF (C), BACE1 (D), total Aβ (E), and Aβ1–42 (F) expression in the mouse cortex (n = 3–5 per group). (G–I) Representative western blots (each row is an image from a different blot) (G) and quantitative analysis of BACE1 (H) and total Aβ (I) expression in the mouse hippocampus (n = 4–5 per group). Data are expressed as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 (one-way analysis of variance followed by Tukey’s post hoc test). APP: Amyloid precursor protein; Aβ: amyloid-β; BACE1: β-site APP cleaving enzyme1; CTF: C-terminal fragment; Ctx: cortex; flAPP: full-length APP; GGT5: gamma-glutamyltransferase 5; Hip: hippocampus; WT: wide type.