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. 2024 Jan 31;20(2):587–597. doi: 10.4103/NRR.NRR-D-23-01414

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miRNA sequencing analysis of sEVs derived from hiPSCs and NPCs.

(A) Volcano plot of differentially expressed miRNAs from hiPSC-sEVs and NPC-sEVs. (B, C) KEGG and GO pathway enrichment analyses of differentially expressed miRNAs. (D) Heatmap of differentially expressed miRNAs related to neural pathways. (E) Expression rank of miRNAs in NPC-sEVs. (F) Pie chart showing the percentage of 17 neuroprotective miRNAs in the top 50 miRNAs in term of expression. DEG: Differentially expressed gene; GO: Gene Ontology; hiPSC: human induced pluripotent stem cell; KEGG: Kyoto Encyclopedia of Genes and Genomes; miRNA: microRNA; NPC: neural progenitor cell; sEV: small extracellular vesicle; TPM: tag per million.