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. 2024 Aug 12;22:756. doi: 10.1186/s12967-024-05567-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 6 — Identification analysis of motifs within phenotype-specific high ALRW scores sequences. (A) The overlap of motifs was determined for four non-overlapping HERV dataset test sets (RUN0-Related, Split1-Related, Split2-Related, Split3-Related); (B) HERV phenotype sequence-specific motif enrichment analysis demonstrated, where the x-axis of the analysis represents the overall rate of HERV type motifs; (C) The multiple motifs-enriched AKR1E2 gene screened by two strategies in RUN0-related test set. ominoidae-specific HERV sequences chr10_ERV1_01040 are highlighted in orange (Hominoidae: Human, Chimp, Bonobo, Gorilla, Gibbon)