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. 2024 Aug 12;22:754. doi: 10.1186/s12967-024-05512-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 4 — Genetic features of SPDO1P and SPDO1LM by whole-exome sequencing. (A) By CNV analysis, the SPDO1P shows a chromosome 8 gain (marked by red) and chromosome 21 loss (marked by blue). (B) By CNV analysis, the SPDO1LM line shows a chromosome 8 gain (marked by red), chromosome 12 gain (marked by red), and chromosome 21 loss (marked by blue). Copy ratio > 0 indicats a gain; copy ratio < 0 indicates a loss. (C) The bar plot of SNP ratios in SPDO1P, SPDO1LM, and their matched original tissues. There is no significant difference in the ratio of SNPs between SPDO1P and its original tissue (^nsP = 0.8832) or SPDO1LM and its original cancer tissue (^nsP = 0.7003) by the Chi-square test. (D) By mutation analysis, 25 somatic driver mutations are shared in both SPDO1P and SPDO1LM lines, as well as their original cancer tissues. There are specific driver mutations in the SPDO1P line and the matched cancer tissue (red box) and SPDO1LM line and matched cancer tissue (blue box)