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. 2024 Aug 12;22:754. doi: 10.1186/s12967-024-05512-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 6 — Drug sensitivity of SPDO1P and SPDO1LM lines and its effect on 3D cell invasion. (A) Left: The morphological changes of SPDO1P (upper) and SPDO1LM (lower) upon 5-Fu treatment. Middle: Cell vitality analysis of organoids compared to cancer cell lines AGS, NCI-N87-2D, and NCI-N87-3D spheroids upon 5-Fu treatment. Right: The bar chart shows IC50 values of organoids and cancer cell lines AGS, NCI-N87-2D, and NCI-N87-3D spheroids. (B) Left: The morphological changes of SPDO1P (upper) and SPDO1LM (lower) upon OXA treatment. Middle: Cell vitality analysis of organoids compared to cancer cell lines AGS, NCI-N87-2D, and NCI-N87-3D spheroids upon OXA treatment. Right: The bar chart shows IC50 values of organoids and cancer cell lines AGS, NCI-N87-2D, and NCI-N87-3D spheroids upon OXA treatment. (C) Left: The morphological changes of SPDO1P (upper) and SPDO1LM (lower) upon PTX treatment. Middle: Cell vitality analysis of organoids compared to cancer cell lines AGS, NCI-N87-2D, and NCI-N87-3D spheroids upon PTX treatment. Right: The bar chart shows IC50 values of organoids and cancer cell lines AGS, NCI-N87-2D, and NCI-N87-3D spheroids upon PTX treatment. n = 3. Scale bar, 100 μm. (D) In 3D cell invasion assays, 5-Fu more significantly inhibits SPDO1LM invasion in SPDO1LM compared to SPDO1P. (E) OXA significantly inhibits SPDO1P invasion compared to SPDO1LM. (F) PTX inhibits both SPDO1P and SPDO1LM invasion compared to controls. ^nsP > 0.05, ^*P < 0.05, ^**P < 0.01, ^***P < 0.001