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. 2024 Aug 12;5(8):e684. doi: 10.1002/mco2.684

FIGURE 1.

FIGURE 1

USP22 is overexpressed in melanoma and associated with a poor prognosis. (A and B) Univariate Cox regression analysis to reveal the association between the USP family and overall survival (A) or disease‐specific survival (B) of melanoma patients. (C) Bioinformatic analysis for the expression of USP22, USP35, USP36, USP43 expression in melanoma (n = 461) and normal skin tissues (n = 558). (D) Kaplan–Meier curves depicting overall survival or disease‐specific survival difference between USP22 high and USP22 low groups. (E) Forest plot showing the results of hazard ratio's (HR) from multivariate Cox regression analysis for the overall survival and disease‐specific survival of melanoma patients. (F) USP22 mRNA expression levels in human melanoma and normal skin data based on Xiangya cohort and two different GSE databases (GSE15605 and GSE46517). (G) USP22 protein levels in normal melanocytes (PIG1) and melanoma cell lines (A375, SK‐Mel‐28, and A2058). (H) Representative images of immunohistochemistry (IHC) staining of USP22 in tissue assay quantified with H‐score.