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. 2024 Apr 15;51(4):320–334. doi: 10.1159/000538550

Table 4.

Sensitivity and specificity of novel metrics with previous standards in entire cohort between surgical CoA and No CoA (N = 110)

Metric Sensitivity, % Specificity, % Confidence interval sensitivity Confidence interval specificity PPV, % NPV, % p value
Novel metrics
 VTI diastolic systolic ratio (>0.31) 32 90 0.21–0.46 0.79–0.96 53 80 <0.01
 AAo-DAo angle (<21 degrees) 100 98 0.94–1.0 0.72–0.98 92 100 <0.01
 TAo-DAo angle (>98 degrees) 100 97 0.94–1.0 0.7–0.96 90 100 <0.01
 LV long strain (<12.8%) 85 96 0.63–0.94 0.68–0.95 88 96 <0.01
Standard metrics
 Combined mitral/aortic Z-score (<−4.1) 39 81 0.27–0.44 0.58–0.89 28 90 0.08
 Flow reversal PFO or aortic arch 47 82 0.37–0.52 0.6–0.92 36 88 0.32

VTI, velocity time interval; AAo, ascending aorta; DAo, descending aorta; TAo, thoracic aorta; LV, left ventricular; PFO, patent foramen ovale.