Table 4.
Sensitivity and specificity of novel metrics with previous standards in entire cohort between surgical CoA and No CoA (N = 110)
Metric | Sensitivity, % | Specificity, % | Confidence interval sensitivity | Confidence interval specificity | PPV, % | NPV, % | p value |
---|---|---|---|---|---|---|---|
Novel metrics | |||||||
VTI diastolic systolic ratio (>0.31) | 32 | 90 | 0.21–0.46 | 0.79–0.96 | 53 | 80 | <0.01 |
AAo-DAo angle (<21 degrees) | 100 | 98 | 0.94–1.0 | 0.72–0.98 | 92 | 100 | <0.01 |
TAo-DAo angle (>98 degrees) | 100 | 97 | 0.94–1.0 | 0.7–0.96 | 90 | 100 | <0.01 |
LV long strain (<12.8%) | 85 | 96 | 0.63–0.94 | 0.68–0.95 | 88 | 96 | <0.01 |
Standard metrics | |||||||
Combined mitral/aortic Z-score (<−4.1) | 39 | 81 | 0.27–0.44 | 0.58–0.89 | 28 | 90 | 0.08 |
Flow reversal PFO or aortic arch | 47 | 82 | 0.37–0.52 | 0.6–0.92 | 36 | 88 | 0.32 |
VTI, velocity time interval; AAo, ascending aorta; DAo, descending aorta; TAo, thoracic aorta; LV, left ventricular; PFO, patent foramen ovale.