Table 5.

Sensitivity and specificity of novel metrics with previous standards in moderate and high risk cohort between surgical CoA and No CoA (N = 65)

Metric	Sensitivity, %	Specificity, %	Confidence interval sensitivity	Confidence interval specificity	PPV, %	NPV, %	p value
Novel metrics
VTI diastolic systolic ratio (>0.31)	45	100	0.27–0.52	0.89–1.0	100	78	<0.01
AAo-DAo angle (<21°)	92	100	0.72–0.99	0.89–1.0	100	97	<0.01
TAo-DAo angle (>98°)	90	100	0.67–0.97	0.89–1.0	100	95	<0.01
LV long strain (<12.8%)	86	100	0.63–0.94	0.89–1.0	100	93	<0.01
Standard metrics
Combined mitral/aortic Z-score (<−4.1)	63	65	0.43–0.74	0.48–0.78	56	77	0.03
Flow reversal PFO or aortic arch	41	79	0.22–0.68	0.61–0.89	50	71	0.21

VTI, velocity time interval; AAo, ascending aorta; DAo, descending aorta; TAo, thoracic aorta; LV, left ventricular; PFO, patent foramen ovale.