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. 2024 Jul 15;15(8):1287–1297. doi: 10.1021/acsmedchemlett.4c00162

Scheme 1. Synthesis of Ketones and Monohydroxyls, and Primary Amines.

Scheme 1

Reaction conditions: (i) NaOtBu, Pd2dba3, (±)-BINAP, THF, 70 °C; (ii) HCl, MeOH; (iii) 1. AcOH, THF/MeOH, 4 Å MS. 2. NaCNBH3; (iv) NaBH4, MeOH; (v) 1. H2NSOC(CH3)3, Ti(OEt)4, THF, 70 °C. 2. NaBH4, MeOH; (vi) HCl, MeOH.