Table 3. Antibacterial Activity vs Salmonella Strains^a.

Cmpd	S. enterica Typhimurium ATCC 14028 MIC (μg/mL)	S. enterica Typhimurium 14028 ΔtolC1::kanb MIC (μg/mL)	Fold Change
6a	64	0.5	128
6b	≥64	1 to >1c	≥64
6c	16	≤0.125	≥128
7a	64	1	64
7b	32	0.25	128
7c	16	≤0.125	≥128
9a	64	4	16
9b	32	2	16
9c	32	4	8
13a	≥64	0.5–1c	≥64
13b	64	0.125	512
13c	16	0.25	64
14a	≥64	1	≥64
14b	64	0.25	256
14c	16	0.5	32
15a	≥64	1–2b	≥64
15b	64	1	64
15c	32	0.25	128
16a	≥64	0.5–1c	≥128
16b	64	0.5	128
16c	64	1	64
21a	≥64	8	≥8
21b	≥64	4	≥16
21c	64	16	4
22a	64	1	64
22b	32	0.25	128
22c	≥64	8	≥8
23a	64	1	64
23b	32	0.125	256
23c	32	0.5	64
40	32	0.5	64
Gep.d	2–8c	0.125–0.5c	4–16
Cipro.d	≤0.13	≤0.13	N/A

^aMinimal inhibitory concentrations (MICs) determined in triplicate (at a minimum) according to CLSI guidelines.¹⁸

^bEfflux-deficient strain EFB044. This strain was constructed by moving mutation ΔtolC1::kan from the McClelland mutant collection²³ into wildtype strain 14028 using P22 transduction.²⁴

^cRanges of observed values given where appropriate.

^dGepotidacin and ciprofloxacin employed as controls.