Fig. 1. Overview of the reaction network of the in silico model of the AA cascade. The model includes intracellular production by enzymatic and non-enzymatic reactions (oxygenation; dehydration; hydrolysis), efflux to the extracellular compartment (ABC transporters) and prostaglandin transporter (PGT) mediated reactions. Abbreviations: arachidonic acid (AA), extracellular prostaglandin H2 (exPGH2), extracellular prostaglandin E2 (exPGE2), extracellular 13,14-dihydro-15-keto-prostalgandin E2 (ex13,14-dihydro-15-keto-PGE2), extracellular 15-keto-prostalgandin E2 (ex15-keto-PGE2), extracellular 6-keto-prostaglandin F1α (ex6-keto-PGF1α), extracellular prostaglandin F1α (exPGF1α), 13,14-dihydro-15-keto-prostaglandin E2 (13,14-dihydro-15-keto-PGE2), 15-deoxy-prostaglandin J2 (15-deoxy-PGJ2), extracellular 15-deoxy-prostaglandin J2 (ex15-deoxy-PGJ2), extracellular thromboxane B2 (exTXB2), thromboxane B2 (TXB2), prostaglandin reductase 2 (PTGR2), prostaglandin F2α (PGF2α), 15-keto-prostaglandin E2 (15-keto-PGE2), 6-keto-PGF1α (6-keto-PGF1α), prostaglandin J2 (PGJ2), extracellular prostaglandin J2 (exPGJ2), extracellular prostaglandin D2 (exPGD2), 15-prostaglandin dehydrogenase (15-PGDH), extracellular thromboxane A2 (exTXA2), thromboxane A2 (TXA2), prostaglandin F synthase (PGFS), prostaglandin E synthase (PGES), prostaglandin E2 (PGE2), prostaglandin I synthase (PGIS), prostaglandin I2 (PGI2), prostaglandin D2 (PGD2), extracellular prostaglandin I2 (exPGI2), thromboxane A synthase (TXAS), prostaglandin H2 (PGH2), prostaglandin D synthase (PGDS), cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), extracellular 12-hydroperoxy-eicosatetraenoic acid (ex12-HPETE), phospholipid hydroperoxide glutathione peroxidase (PHGPx), 12-lipoxygenase (12-LOX), 15-lipoxygenase (15-LOX), extracellular 15-hydroxy-eicosatetraenoic acid (ex15-HETE), extracellular 15-hydroperoxy-eicosatetraenoic acid (ex15-HPETE), extracellular 12-hydroxy-eicosatetraenoic acid (ex12-HETE), 12-hydroperoxy-eicosatetraenoic acid (12-HPETE), 15-hydroxy-eicosatetraenoic acid (15-HETE), extracellular arachidonic acid (ex-AA), 5-lipoxygenase (5-LOX), 5-hydroperoxy-eicosatetraenoic acid (5-HPETE), extracellular 5-hydroperoxy-eicosatetraenoic (ex5-HPETE), extracellular 5-hydroxy-eicosatetraenoic acid (ex5-HETE), 5-hydroxy-eicosatetraenoic acid (5-HETE), 5-hydroxyeicosanoid dehydrogenase (5-HEDH), 5-oxo-eicosatetraenoic acid (5-oxo-ETE), extracellular 5-oxo-eicosatetraenoic acid (ex5-oxo-ETE), leukotriene A4 (LTA4), leukotriene C4 synthase (LTC4S), leukotriene A4 hydrolase (LTA4H), leukotriene B4 (LTB4), leukotriene C4 (LTC4), extracellular leukotriene B4 (exLTB4), extracellular leukotriene A4 (exLTA4), extracellular leukotriene C4 (exLTC4), ATP-binding cassette transporter (ABC), prostaglandin transporter (PGT).
