Fig. 2. log-normal distribution of COX-1^48,49 (A), COX-2^50–52 (B), and 12-LOX^53–56 (C) K_ms values and resultant predictions of PGE₂ (D) and 12-HETE (E) concentration by an ensemble model (1000 model variants). The dashed orange line represents published values and the height corresponds to the weighting score from the parameter estimation pipeline.³¹ The source of this demonstration data was the HaCaT model of indomethacin (IND) + calcium ionophore (A23187) stimulated in silico model (“HaCaT + IND + A23187”).