Table 1.

Identification of the Top 5 Hub Genes

Gene Symbol	Gene Name	Protein Function
RPL7A	Large ribosomal subunit protein eL8; Ribosomal protein L7a	The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell
NHP2L1	NHP2 Non-Histone Chromosome Protein 2-Like 1	Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding
PSMD11	Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity
RRP15	Ribosomal RNA processing 15 homolog	Maturation of 5.8S rRNA. Maturation of LSU-rRNA
POLR2K	RNA Polymerase II, I and III Subunit K RPABC4	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors of many functional non-coding RNAs and small RNAs such as 5S rRNA and tRNAs, respectively.