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. 2024 Jul 31;20(7):e1011950. doi: 10.1371/journal.ppat.1011950

Fig 1. Trans-complementation rescues LPKO virus infected naïve B cells.

Fig 1

A. Schematic of experimental design. B. Outgrowth of tdTomato positive cells over time (n = 3). WT infected cells are indicated with dashed lines, while LPKO infected cells are solid lines. C. Total tdTomato positive cells in each condition at 14 days post-infection (n = 3). P values from unpaired t-test. Mean and standard deviation are plotted. D. Total tdTomato positive cells at the final time point for each donor, 28 or 35 days post-infection (n = 3). E. Number of tdTomato positive LCLs generated per condition. #Indicates conditions in which tdTomato negative LCLs were generated. P values calculated using Fisher’s exact test to compare transformation outcomes to LPKO + Vector. **** indicates a p value < 0.0001. F. EBNA-LP expression in trans-complemented LPKO LCLs and WT LCLs. W indicates number of W domains in EBNA-LP protein expressed from virus or expression construct. M indicates molecular weight marker.