Table 3.
Baseline Characteristics of Female Rotterdam Study Participants, Including Individuals With and Without Migraine
| Female participants | All (n = 4,181) | With (a history of) migraine (n = 884) | Without (a history of) migraine (n = 3,297) |
| Aura (%) | 184 (4.4) | 184 (20.8) | — |
| Age (y) | 66.8 [56.4−75.1] | 62.6 [55.4−72.8] | 67.2 [56.7−75.7] |
| Education level (%) | |||
| Primary education | 455 (10.9) | 80 (9.0) | 375 (11.4) |
| Lower/intermediate general education or lower vocational education | 2097 (50.2) | 432 (48.9) | 1,665 (50.5) |
| Intermediate vocational education or higher general education | 989 (23.7) | 213 (24.1) | 776 (23.5) |
| Higher vocational education or university | 640 (15.3) | 159 (18.0) | 481 (14.6) |
| BMI (kg/m2) | 27.0 [24.3−30.2] | 27.2 [24.2−30.3] | 26.9 [24.3−30.2] |
| Obesity (BMI >30 kg/m2) | 1,092 (26.1) | 236 (26.7) | 856 (26.0) |
| Waist-to-hip ratio | 0.84 [0.79−0.89] | 0.84 [0.79−0.89] | 0.84 [0.80−0.90] |
| Systolic blood pressure (mm Hg) | 138 [123−155] | 137 [123−154] | 138 [124−156] |
| Diastolic blood pressure (mm Hg) | 83 [76−91] | 83 [77−92] | 83 [76−91] |
| Hypertension (%) | 2,783 (66.6) | 579 (65.5) | 2,204 (66.8) |
| Antihypertensive drug use (%) | 1,655 (39.6) | 341 (38.6) | 1,314 (39.9) |
| Total cholesterol (mmol/L) | 5.6 [5.0−6.3] | 5.6 [5.0−6.3] | 5.6 [5.0−6.3] |
| High-density lipoprotein cholesterol (mmol/L) | 1.5 [1.3−1.8] | 1.5 [1.3−1.8] | 1.5 [1.3−1.9] |
| Triglycerides (mmol/L) | 1.2 [0.9−1.7] | 1.3 [0.9−1.7] | 1.2 [0.9−1.7] |
| Hypercholesterolemia (%) | 2,133 (51.0) | 459 (51.9) | 1,674 (50.8) |
| Lipid-lowering medication use (%) | 990 (23.7) | 220 (24.9) | 770 (23.4) |
| Fasting glucose levels (mmol/L) | 5.3 [5.0−5.8] | 5.3 [4.9−5.7] | 5.3 [5.0−5.8] |
| Diabetes mellitus (%) | 418 (10.0) | 71 (8.0) | 347 (10.5) |
| Smoking status (%) | |||
| Former | 1782 (42.6) | 403 (45.6) | 1,379 (41.8) |
| Current | 744 (17.8) | 129 (14.6) | 615 (18.7) |
| Pack-years of ever smokers | 13.8 [4.0−30.0] | 9.9 [2.5−26.8] | 15.0 [4.5−30.3] |
| Alcohol consumption (gram/day) | 2.0 [0.5−8.6] | 1.6 [0.5−8.6] | 3.8 [0.5−8.6] |
| Physical activity (MET hours/week) | 40.1 [15.0−81.2] | 39.5 [15.0−75.3] | 40.5 [15.0−82.1] |
Abbreviations: BMI = body mass index; MET = metabolic equivalent of task.
Note: Imputed and unadjusted values of the cohort, with and without stratification for the migraine diagnosis, are displayed as means (SD) or medians [interquartile range, Q3–Q1] or as numbers (percentage). Shapiro-Wilk normality test was used to assess normality.