Table 5.

Association of Continuous Cardiovascular Determinants and Migraine, Stratified by Sex

Cardiovascular Risk factor	Model 1		Model 2		Model 3
	Female participants	Male particpants	Female participants	Male particpants	Female participants	Male particpants
Pack-years	0.99 [0.99−1.00]	1.00 [0.99−1.01]	0.92 [0.84−1.00]	1.03 [0.87−1.22]	0.91 [0.84−1.00]	1.04 [0.87−1.24]
Total cholesterola	0.99 [0.92−1.07]	0.99 [0.85−1.16]	1.00 [0.92−1.08]	1.05 [0.89−1.25]	0.97 [0.89−1.05]	1.04 [0.87−1.25]
HDL-cholesterola	0.84 [0.70−1.01]	1.26 [0.80−1.98]	0.95 [0.88−1.03]	1.15 [0.97−1.36]	0.96 [0.88−1.06]	1.16 [0.95−1.41]
Triglyceridesa	1.08 [0.97−1.20]	0.94 [0.80−1.10]	1.05 [0.97−1.13]	0.96 [0.80−1.15]	1.06 [0.96−1.16]	1.01 [0.82−1.23]
Systolic blood pressureb	1.00 [1.00−1.01]	1.00 [0.99−1.00]	1.06 [0.97−1.16]	0.96 [0.80−1.14]	0.95 [0.84−1.07]	0.98 [0.77−1.26]
Diastolic blood pressureb	1.01 [1.00−1.02]	0.99 [0.98−1.01]	1.13 [1.04−1.22]	0.95 [0.80−1.12]	1.16 [1.04−1.29]	0.96 [0.76−1.22]
BMIc	1.01 [0.99−1.02]	0.98 [0.94−1.03]	1.03 [0.95−1.11]	0.95 [0.81−1.13]	1.01 [0.93−1.10]	0.99 [0.83−1.19]
Fasting glucose levelsa	0.94 [0.87−1.01]	1.02 [0.90−1.15]	0.92 [0.85−1.00]	1.04 [0.88−1.22]	0.90 [0.82−0.98]	1.06 [0.89−1.25]

Model 1 is unadjusted.

Model 2 is adjusted for Rotterdam Study cohort, alcohol consumption, physical activity, and educational level. All continuous risk factors have been expressed as a Z-score for females and males separately.

Model 3 is adjusted for former smoking, current smoking, total cholesterol, HDL-cholesterol, triglycerides, systolic BP, diastolic BP, BMI, fasting glucose levels, Rotterdam Study cohort, alcohol consumption, physical activity, and educational level. All continuous risk factors have been expressed as a Z-score for females and males separately.

^aExpressed in mmol/L.

^bExpressed in mm Hg.

^cExpressed in kg/m².