TABLE 4.
Histopathologic Tissue Reaction to Synthetic Bone Graft According to ISO 10992-6:2016
| Cell type/response | SBG level | Control level | ||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | |
| Polymorphonuclear cells | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Lymphocytes | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Plasma cells | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Macrophages | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Giant cells | (3+0+0) | (1+1+0) | (0+2+0) | 0 | 0 | 0 | 0 | 0 |
| Necrosis | 0 | 0 | (1+2+1) | 0 | (3+3+3) | 0 | (1+3+2) | 0 |
| Average subtotal×2 | 2 | 1,3 | 4 | 0 | 6 | 0 | 4 | 0 |
| Neovascularization | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Fibrosis | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Fatty infiltrate | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Subtotal×1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Total tissue response | 2 | 1,3 | 4 | 0 | 6 | 0 | 4 | 0 |
| Group total | 7,3 | 10 | ||||||
| Average* | 1,8 (-) | 2,5=−0,7 | ||||||
| Conclusion | −0,7=0, Minimal or no reaction (0,0 to 2,9) | |||||||
| Traumatic necrosis | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Foreign debris (synthetic bone graft) | (3+3+0) | (2-2-0) | (0+3+1) | (0+1+0) | 0 | 0 | 0 | 0 |
| Degradation of synthetic bone graft | (3+3+1) | (3+3+0) | (0+3+3) | (NA+3 +NA) | NA | NA | NA | NA |
Histopathologic evaluation of one left, central and right sagittal section for each animal at synthetic bone graft (SBG) and control level. Score 0 represent a score of 0 for all sections evaluated within that group. Scores in brackets represent the score of the left, central, and right sagittal section, respectively.
*
A negative difference is recorded as zero in activity ranking in conclusion.
NA indicates not applicable; SBG, synthetic bone graft.