TABLE 3.
Pathogen Detection and Laboratory Values by Age Groups
| Patient Age | 0–4 Years n = 32 | 5–10 Years n = 37 | ≥11 Years n = 33 | Total n = 102 |
|---|---|---|---|---|
| Pathogen detection | ||||
| Blood culture | ||||
| N positive/N specimens (% positivity rate) | 8/29 (28%) | 21/35 (60%) | 26/30 (87%) | 55/94 (59%) |
| Pathogen (% of all positive cultures) |
S. aureus: n = 4 (50%) S. pyogenes: n = 2 (25%) S. pneumoniae: n = 1 Micrococcus luteus: n = 1 |
S. aureus: n = 11 (52%) S. pyogenes: n = 9 (43%) Salmonella Gr. D: n = 1 |
S. aureus: n = 20 (77%) E. coli: n = 3 (12%) S. pyogenes: n = 1 Others: n = 2* |
S. aureus: n = 35 (64%) S. pyogenes: n = 12 (22%) E. coli: n = 3 (6%) Others: n = 5 (11%) |
| Tissue culture | ||||
| N positive/N specimen (% positivity rate) | 17/21 (81%) | 18/20 (90%) | 16/18 (89%) | 51/59 (86%) |
| Pathogen (% of all positive cultures) |
S. pyogenes: n = 6 (35%) Kingella kingae†: n = 6 (35%) S. pneumoniae: n = 2 (12%) S. aureus: n = 2 (12%) Others: n = 1‡ (6%) |
S. aureus: n = 9§ (50%) S. pyogenes: n = 7 (39%) Enterobacter spp.: n = 1 (5%) Others: n = 1¶ (5%) |
S. aureus: n = 9 (56%) E. coli: n = 3 (19%) S. pneumoniae: n = 2 (13%) S. pyogenes: n = 1 (6%) S. lugdunensis: n = 1(6%) |
S. aureus: n = 20§ (39%) S. pyogenes: n = 14 (27%) Kingella kingae†: n = 6 (12%) S. pneumoniae: n = 4 (8%) Others: n = 7 (14%) |
| Any | ||||
| N patients with any positive (% of all patients) | 21 (66%) | 30 (82%) | 32 (97%) | 83 (81%) |
| Pathogen (% of all positive cultures) |
S. pyogenes: n = 7 (33%) Kingella kingae: n = 6 (29%) S. aureus: n = 5 (24%) S. pneumoniae: n = 2 (10%) Others: n = 1 (5%) |
S. aureus: n = 16 (53%) S. pyogenes: n = 11 (37%) Others: n = 3 (10%) |
S. aureus: n = 21 (66%) E. coli: n = 4 (13%) S. pyogenes: n = 2 (6%) S. pneumoniae: n = 2 (6%) Others: n = 3 (9%) |
S. aureus: n = 42 (51%) S. pyogenes: n = 20 (24%) Kingella kingae: n = 6 (7%) S. pneumoniae: n = 4 (5%) E. coli: n = 4 (5%) Others: n = 7 (8%) |
| Laboratory values | ||||
| WBC N patients with ≥1 done (% of all patients) |
32 (100%) |
37 (100%) |
32 (97%) |
101 (99%) |
| Baseline mean WBC on admission (×109/L), median [IQR] | 17.7 [12.9–23.2] | 14.4 [9.8–18.6] | 10.25 [7–14.4] | 13.95 [8.9–19.4] |
| Maximal mean WBC value (×109/L), median [IQR] | 17.7 [13.8–23.2] | 15.5 [10.6–20.1] | 12.4 [9.5–18.3] | 15.8 [10.7–19.9] |
| CRP N patients with ≥1 done (% of all patients) |
32 (100%) |
37 (100%) |
33 (100%) |
102 (100%) |
| Baseline mean CRP on admission (mg/L), median [IQR] | 71 [51–129] | 97 [52–155] | 100 [44–152] | 90 [50.3–149.3] |
| Maximal mean CRP (mg/L), median [IQR] | 99.5 [65.2–147.8] | 129 [78–221] | 162 [84–213.1] | 130.5 [71.3–190.8] |
| ESR N patients with ≥1 done (% of all patients) |
22 (69%) |
26 (70%) |
24 (72%) |
72 (71%) |
| Baseline mean ESR on admission(mm/h), median [IQR] | 63.5 [47–83.75] | 53.5 [35–67.8] | 36 [17.75–60.75] | 52.5 [27.3–68.3] |
| Maximal mean ESR value (mm/h), median [IQR] | 67 [48–85] | 52 [36–74] | 48.5 [26.3–84] | 57.5 [35–84.5] |
*
Others: Concomitant Candida parapsilosis and Enterococcus spp. (n = 1); polymicrobial infection (self-contaminated peripherally inserted central catheter line; n = 1).
†
Abscess puncture plus PCR positive throat swab (n = 2), joint puncture plus PCR positive throat swab (n = 1); PCR positive throat swabs only (n = 3; see Methods section).
‡
Others: Streptococcus agalactiae (n = 1).
§
Concomitant Klebsiella pneumoniae isolation from tissue culture in one patient.
¶
Others: Group C streptococcus.