Table 2.
PPH signals were enriched (P < 0.05, Bonferroni corrected) within binding sites for progesterone receptor (PGR) defined in human embryonic stem cells (hESC)
| DNA binding protein | Tissue or cell line | Annotated PPH signals, n | Expected proportion of annotated PPH signals (%) | P value |
|---|---|---|---|---|
| PGR | hESC | 4/5 | 5 | 5 × 10−6 |
| ZNF558 | HEK293 | 4/5 | 27 | 7 × 10−5 |
| PGR | Myometrium | 5/5 | 17 | 0.001 |
| PGR | Leiomyoma | 3/5 | 8.6 | 0.002 |
| IRF2BP2 | HEK293 | 3/5 | 9.9 | 0.005 |
| MED12 | Leiomyoma | 3/5 | 11 | 0.007 |
| MYOG | RH4 | 3/5 | 11 | 0.009 |
| MED12 | Myometrium | 3/5 | 14 | 0.01 |
| ONECUT1 | Hep-G2 | 3/5 | 15 | 0.019 |
| FOXA1 | Prostate | 4/5 | 17 | 0.02 |
| ZNF3 | Hep-G2 | 3/5 | 7 | 0.023 |
Shown are nominally significant results; that is, where uncorrected P < 0.05. We defined binding sites by ChIP–seq data available through the Remap2022 database (remap.univ-amu.fr).