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. 2024 Aug 5;56(8):1592–1596. doi: 10.1038/s41588-024-01844-1

Fig. 1. Association between reported influenza infection in the AncestryDNA cohort and 24 variants previously reported to be associated with COVID-19 outcomes by the HGI.

Fig. 1

Of the 24 COVID-19 risk variants, 16 were discovered in a GWAS of COVID-19 hospitalization (comparing 25,027 cases hospitalized with COVID-19 against 2,836,272 individuals with no record of SARS-CoV-2 infection), while eight were discovered in a GWAS of reported SARS-CoV-2 infection (comparing 125,415 individuals with a record of SARS-CoV-2 infection against 2,575,157 individuals with no record of SARS-CoV-2 infection). Of the 24 variants, only one (rs505922, 9:133273813:C:T, in ABO), was associated with reported influenza (18,334 cases versus 276,295 controls) after Bonferroni correction for 24 tests (P = 0.002, obtained using Firth regression, two-sided test); however, the direction of effect for influenza (blue circles) was the opposite of that reported for COVID-19 (red diamonds). The error bars represent the 95% CI for the OR estimate.