Table 1.
Two loci identified in a multiancestry meta-analysis of reported influenza infection performed in the AncestryDNA cohorta and validated in an independent meta-analysis consisting of seven biobanks with electronic medical recordsb
| Variant (effect allele) | Analysis | OR (95% CI) | P | Effect allele frequency in cases/controls | Homozygote OR (95% CI) |
|---|---|---|---|---|---|
| Chromosome 3q27.3, nearest gene ST6GAL1 | |||||
| rs16861415 (C) | Discovery | 0.864 (0.826–0.903) | 1.4 × 10−10 | 0.064/0.074 | 0.627 (0.489–0.804) |
| Replication | 0.901 (0.872–0.930) | 3.3 × 10−10 | 0.094/0.097 | 0.802 (0.717–0.894) | |
| Chromosome 21q22.2, nearest gene B3GALT5 | |||||
| rs2837112 (A) | Discovery | 0.901 (0.882–0.922) | 1.3 × 10−19 | 0.460/0.485 | 0.824 (0.789–0.860) |
| Replication | 0.936 (0.917–0.954) | 4.1 × 10−11 | 0.432/0.461 | 0.877 (0.843–0.913) | |
a18,334 cases versus 276,295 controls in the discovery analysis. bUK Biobank (UKB), GHS, PMBB, CCPM, Mayo Clinic, UCLA and FinnGen consisting of 22,022 cases and 1,131,269 controls in the replication analysis. Unadjusted P values were derived using Firth regression (two-sided test) as implemented in REGENIE9.