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. 2024 Jun 11;49(10):1609–1618. doi: 10.1038/s41386-024-01870-x

Fig. 1. GWAS and secondary analyses of coffee intake from the 23andMe cohort.

Fig. 1

A Manhattan plot displays seven genome-wide significant loci associated with coffee intake in the 23andMe cohort (N = 130,153). The horizontal line represents the threshold for significance (p = 5.00E−08). Nearest protein-coding genes (<1 Mb) to significant loci are labeled. Quantile-quantile plot shown in upper left corner. For more details, see Table 1 and Supplementary Table 6. B Overlap of genes identified by MAGMA, H-MAGMA, S-PrediXcan, and S-MultiXcan. Genes identified by all four methods are displayed. C Genes implicated in coffee intake by S-PrediXcan according to brain regions. Upregulated genes are shown in red, downregulated shown in blue.