Figure 1.

(A) Nucleotide sequence of the 3′ end of the lama3 regulatory region. Nucleotide numbering is relative to the first nucleotide of the transcription initiation site (+1). The three AP-1 binding sites are underlined, the two putative E-box motifs are open boxes and the USF responsive element (Ebox3) is the shaded box. The numbers refer to the position of the deleted sequences. Asterisks represent the multiple transcription start sites identified by primer extension analysis. The translation start site is identified by a dot. (B) Primer extension on lama3 mRNA isolated from human primary keratinocytes are shown. The primer used is indicated by an arrow.