Table 3.

True positive rates (TPR) by causal SNP pairs based on bootstrap results.

Causal pair	SNP1 p-value (p-main)1	SNP2 p-value (p-main)1	SNP–SNP interaction p-value (p-pair)1	Bootstrap2
				1pRule TPR%3	3pRule TPR%3
rs17632542–rs4783709	2.2 × 10–15	0.027	5.7 × 10–18	95.0	91.8
rs2569735–rs7613553	5.5 × 10–9	0.551	4.4 × 10–13	98.2	98.0
rs1058205–rs2274545	9.5 × 10–8	0.065	2.0 × 10–9	83.6	81.0
rs4802755–rs4473378	1.8 × 10–7	0.728	2.3 × 10–9	86.6	86.0
rs174776–rs1250240	7.9 × 10–7	0.279	2.4 × 10–9	94.0	93.8
rs2271095–rs7446	2.0 × 10–6	2.0 × 10–5	1.7 × 10–12	95.4	94.4
rs266876–rs9521694	3.2 × 10–6	0.001	3.4 × 10–9	77.0	75.6

¹Bold for significant results based on the Bonferroni criteria. p-main < 8.1 × 10^–5 (= 0.05/614), and p-pair < 2.7 × 10^–7 (= 0.05/⁶¹⁴C₂).

²Based on 500 bootstrap datasets with a sample size of 20,000 and 614 SNPs (7 causal pairs + 600 null SNPs).

³Significance rules: 1pRule: p-pair < 2.7 × 10^–7; 3pRule: p-pair < 2.7 × 10^–7, p-pair < p-main for SNP1, and p-pair < p-main for SNP2.