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. 2024 Jul 8;16(8):1930–1956. doi: 10.1038/s44321-024-00096-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the data associated with this article, unless otherwise stated in a credit line to the data, but does not extend to the graphical or creative elements of illustrations, charts, or figures. This waiver removes legal barriers to the re-use and mining of research data. According to standard scholarly practice, it is recommended to provide appropriate citation and attribution whenever technically possible.

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Figure EV4 — (A, B) Original traces of PAP in the IPL model during perfusion with DMSO (A) or FR (10⁻⁶M, B) and exposure to hypoxic air (0% O₂/100% N₂). (C) Statistical analysis of PAP increase evoked by hypoxic air during DMSO (n = 7 mice) or FR (n = 6 mice) perfusion. (D) Statistical analysis of basal RVSP 1 h after DMSO (n = 8) or FR (2.5 µg/mouse, n = 8) i.t. application in healthy mice housed under normoxic (21% O₂) conditions. (E) Statistical analysis of basal heart rate in these mice (DMSO: n = 8; FR: n = 8). (F) Statistical analysis of RVSP increase in response to 5-HT (5 × 10⁻³M, 10 µl) i.v. bolus injection in these mice (DMSO: n = 8; FR: n = 8). (G) Basal heart rate 1 h after DMSO (n = 9) or FR (2.5 µg/mouse, 1 h before, n = 8) application in mice with pre-existing Hx-induced PH (DMSO: n = 9; FR: n = 8). (H, I) Relative change of LVSP (H) and RVSP (I) after acute DMSO (n = 4) or FR (10 µg/mouse i.p., n = 5) application in mice with pre-existing Hx-induced PH. Data information: Values are expressed as mean ± SEM. (C–G) Unpaired student’s t-test. (H, I) Two-way ANOVA, Bonferroni post hoc test. Source data are available online for this figure.